The assessment of percutaneous permeation of molecules is a key step in the evaluation of dermal or transdermal delivery systems....
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- MORE COMMONLY USED MODELS TO CONDUCT SKIN-PERMEATION STUDIES ARE EX VIVO HUMAN OR ANIMAL SKIN. THROUGH THE STANDARDIZATION OF PROTOCOLS.
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Skin models for the testing of transdermal drugs
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Physiology, Biochemistry, and Molecular Biology of the Skin. As we have already noted, if the dosage form is to be used in humans, the most relevant skin-absorption data should come from in vivo human studies. However, they are not intended to represent, nor are they capable of, representing the multitude of in vivo skin properties. In vivo assessment of enhanced topical delivery of terbinafine to human stratum corneum.
Yu et al
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As noted earlier, the SC represents the main barrier to penetration of exogenous substances into the skin, 8 as well as controlling the loss of water from inside the body. A wide range of animal models has been used as alternatives to human skin to evaluate percutaneous permeation of substances. The assessment of percutaneous absorption of molecules is an important step in the evaluation of any topical drug-delivery system or formulation. Artificial and reconstructed skin models Artificial and reconstructed skin models are useful tools in specific circumstances, driven by the need to find convenient, reproducible alternatives to in vivo and ex vivo tests with human and animal skin.
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